Название книги: Evaluation of Enzyme Inhibitors in Drug Discovery

Автор: Robert A. Copeland

ISBN: 9781118540404

Издательство: John Wiley & Sons Limited

Год: 2018

Кол-во стр.: 572

Evaluation of Enzyme Inhibitors in Drug Discovery
equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid.
Second Edition
drug-target residence time
Evaluation of Enzyme Inhibitors in Drug Discovery
begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers:
Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development.
Second Edition
Evaluation of Enzyme Inhibitors in Drug Discovery
continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.